We are conducting research to develop genetically modified common marmosets and to advance gene modification technologies. Recent breakthroughs in gene-editing technologies have significantly simplified the creation of genetically modified non-human primate animals. We have successfully created gene knockout marmosets and developed disease models involving specific gene mutations using gene-editing technologies such as Zinc Finger Nuclease, TALEN, and CRISPR/Cas9. These advancements have expanded the potential of genetically modified marmosets as models for human-specific conditions, including neurodegenerative diseases and psychiatric disorders.
However, efficient methods for precise gene knock-in and large-scale genetic modifications in marmosets have yet to be established. We are working to develop more advanced gene modification methods using gene-editing tools, viral vectors, and other approaches. Since primates produce far fewer embryos and offspring than rodents such as mice, more efficient and precise techniques for gene modifications are required. Additionally, non-human primate animal research must minimize the number of animals used while maximizing scientific outcomes due to consideration of animal ethics. To achieve this, we are working to enhance the accuracy and efficiency of existing gene modification methods. Furthermore, we welcome collaborative research with you on marmosets and their genetic modification.