Department of Biological Functions and Regulation

Laboratory of Animal Husbandry and Management

CIEM has created various disease models, such as immunodeficiency marmosets and Alzheimer's model marmosets, using transgenic and gene editing technologies. It is crucial to rase these animal models in a healthy manner to prevent them from suffering from other diseases, enabling effective research. Since marmosets have a long life span of 10-20 years, we are developing management techniques to ensure that the animals can maintain their health throughout their lives.
For example, marmosets are social animals that live in family groups in the wild, consisting of parents and offspring. To simulate their natural environment, we have created new family cages and are investigating the optimal size of these cages as well as the types of environmental enrichment necessary for their proper development.

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※References
  1. Development of a 3D tracking system for multiple marmosets under free-moving conditions.
    Yurimoto T, Kumita W, Sato K, Kikuchi R, Oka G, Shibuki Y, Hashimoto R, Kamioka M, Hayasegawa Y, Yamazaki E, Kurotaki Y, Goda N, Kitakami J, Fujita T, Inoue T, Sasaki E.
    Commun Biol. 2024 Feb 21;7(1):216.
  2. Early parental deprivation during primate infancy has a lifelong impact on gene expression in the male marmoset brain.
    Shinohara H, Meguro-Horike M, Inoue T, Shimazu M, Hattori M, Hibino H, Fukasawa K, Sasaki E, Horike SI.
    Sci Rep. 2024 Jan 3;14(1):330.
  3. The common marmoset in biomedical research: experimental disease models and veterinary management.
    Inoue T, Yurimoto T, Seki F, Sato K, Sasaki E.
    Exp Anim. 2023 May 17;72(2):140-150.

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